Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity). DCUP_THET8 341 TTHA0601 hemE Uroporphyrinogen decarboxylase MDLVNDLILRAARGEPTPRPPVWFMRQAGRYQKAYRKLRERYTLPEIVQNPEVCAEVTLLPVKALGVDAAILFADITTPLYGMGVDLSLVENKGPVIHNPVRDEKGVEALRPLVPEEAVPFVLETIRILKRELPVPLIGFAGAPFTLASYLVEGGPSRRFLRVKALMYGEEALWHRLMEKLTEAMARYLRAQAEAGADLLQVFDSWVGALSPADYRRYVKPHMERLFQSLRPVGVPVIHFGVGTMGLLEDMKEAGGDVLGLDHHTPLPWARALLGATPVQGNLDPAVLLAPKGVIRREVQRILKENGGKSGHIFNLGHGIVPETPEENVRYVVELIQEVAA